منابع مشابه
Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.
Peptide hormones and neuropeptides have important roles in physiology and therefore the regulation of these bioactive peptides is of great interest. In some cases proteolysis controls the concentrations and signaling of bioactive peptides, and the peptidases that mediate this biochemistry have proven to be extremely successful drug targets. Due to the lack of any general method to identify thes...
متن کاملMass Spectrometry-based Peptidomics for the Discovery of Antimicrobial Peptides
Most antimicrobial peptides (AMPs) are cationic molecules with a high content of basic amino acids. They often undergo C-terminal amidation that may be related to their antimicrobial activity. Here we describe a mass spectromety (MS)-based approach for identifying novel AMPs. MS is used to profile peptides secreted by endocrine cells. Peptide sequences characteristic of AMPs are selected to tes...
متن کاملQuantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus.
In mammals the suprachiasmatic nucleus (SCN), the master circadian clock, is sensitive to light input via the optic chiasm and synchronizes many daily biological rhythms. Here we explore variations in the expression levels of neuropeptides present in the SCN of rats using a label-free quantification approach that is based on integrating peak intensities between daytime, Zeitgeber time (ZT) 6, a...
متن کاملPlant antimicrobial peptides
Pathogens, like fungi, nematodes, virus and bacterial are responsible for several human and plant diseases. According FAO, around 20 to 40 percent of crops yields are lost, per year, due plant diseases and pest. Besides this, only USA spend 30 billion dollars a year with hospital infections, and the numbers are increasing as the infection are becoming more and more resistant to conventional ant...
متن کاملPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining
Cyclotides are plant-derived mini proteins. They are genetically encoded as precursor proteins that become post-translationally modified to yield circular cystine-knotted molecules. Because of this structural topology cyclotides resist enzymatic degradation in biological fluids, and hence they are considered as promising lead molecules for pharmaceutical applications. Despite ongoing efforts to...
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ژورنال
عنوان ژورنال: Plant Biotechnology Journal
سال: 2008
ISSN: 1467-7644,1467-7652
DOI: 10.1111/j.1467-7652.2007.00315.x